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KMID : 0378019860290030132
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New Medical Journal
1986 Volume.29 No. 3 p.132 ~ p.136
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Clinical Efficacy of Oral Pirbuterol in Asthmatic Children
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Abstract
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We studied the effects of an oral B2 selective bronchodilator, pirbuterol, [2-hydrox methyl-3-hydroxy-6-(1-hydroxy-2-tert-butylaminoethyl) pyridine], in 25 asthmatic chili ren. Pirbuterol syrup(Exirel*) was orally administered in four divided doses over 1 week. ach child was evaluated by physical examination, blood analysis, urinalysis, electrocardiog am, and pulmonary function tests twice at admission and 1 week after.
Clinical improvement was noted in 80% of 25 asthmatic children. Disappearance of abnormal breathing sounds were noted as wheezing sound in 72%, rhonchi in 70%, and rales in 55%/ of the cases.
The pulmonary function tests with pirbuterol therapy improved significantly like as 1 VC was increases 1.5 times compared with that of admission in 72% of the cases(p<0. il), FEV 1.0% above 70% was noted in 80% of cases and Peak Flow was also improved in ´0% of the cases (p<0.01). Side effects were noted only in 3 cases such as dizziness and headache.
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